Synchronization in G0/G1 enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin

@inproceedings{Bonnesen2009SynchronizationIG,
  title={Synchronization in G0/G1 enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin},
  author={Christine Bonnesen and Gitte-Mai Nelander and Bo Falck Hansen and Pia Jensen and J Steenbuch Krabbe and Marianne Blirup Jensen and Anne Charlotte Hegelund and Jette Eldrup Svendsen and Martin B. Oleksiewicz},
  booktitle={Cell Biology and Toxicology},
  year={2009}
}
Evaluating mitogenic signaling specifically through the human insulin receptor (IR) is relevant for the preclinical safety assessment of developmental insulin analogs. It is known that overexpression of IR sensitizes cells to the mitogenic effects of insulin, but it is essentially unknown how mitogenic responses can be optimized to allow practical use of such recombinant cell lines for preclinical safety testing. We constitutively overexpressed the short isoform of the human insulin receptor… CONTINUE READING

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