Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women.

@article{Licinio1998SynchronicityOF,
  title={Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women.},
  author={Julio Licinio and Anadr{\'e} B. Negr{\~a}o and Christos Socrates Mantzoros and Virginia G. Kaklamani and May Lai-Ying Wong and Peter B. Bongiorno and Abeda Mulla and Laura R. Cearnal and Johannes D. Veldhuis and Jeffrey S. Flier and S. M. Mccann and PhilipW. Gold},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 5},
  pages={
          2541-6
        }
}
Leptin, an adipocyte hormone, is a trophic factor for the reproductive system; however, it is still unknown whether there is a dynamic relation between fluctuations in circulating leptin and hypothalamic-pituitary-ovarian (HPO) axis hormones. To test the hypothesis that fluctuations in plasma leptin concentrations are related to the levels of luteinizing hormone (LH) and estradiol, we sampled plasma from six healthy women every 7 min for 24 h during days 8-11 of the menstrual cycle. Cross… CONTINUE READING

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Licinio et al

  • W. G. Rossmanith, Yen, 65 S.S.J.Clin.Endocrinol.Metab., 715–718. 2546 Medical Sciences
  • Proc. Natl. Acad. Sci. USA 95
  • 1998
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