Synaptotagmins interact with APP and promote Aβ generation

  title={Synaptotagmins interact with APP and promote Aβ generation},
  author={Vivek Gautam and Carla D’Avanzo and Oksana Berezovska and Rudolph E. Tanzi and Dora M. Kovacs},
  booktitle={Molecular Neurodegeneration},
Accumulation of the β-amyloid peptide (Aβ) is a major pathological hallmark of Alzheimer’s disease (AD). Recent studies have shown that synaptic Aβ toxicity may directly impair synaptic function. However, proteins regulating Aβ generation at the synapse have not been characterized. Here, we sought to identify synaptic proteins that interact with the extracellular domain of APP and regulate Aβ generation. Affinity purification-coupled mass spectrometry identified members of the Synaptotagmin… CONTINUE READING
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