Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment

@article{Adolfsen2004SynaptotagminsAT,
  title={Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment},
  author={Bill Adolfsen and Sudipta Saraswati and Motojiro Yoshihara and J. Troy Littleton},
  journal={The Journal of Cell Biology},
  year={2004},
  volume={166},
  pages={249 - 260}
}
The synaptotagmin family has been implicated in calcium-dependent neurotransmitter release, although Synaptotagmin 1 is the only isoform demonstrated to control synaptic vesicle fusion. Here, we report the characterization of the six remaining synaptotagmin isoforms encoded in the Drosophila genome, including homologues of mammalian Synaptotagmins 4, 7, 12, and 14. Like Synaptotagmin 1, Synaptotagmin 4 is ubiquitously present at synapses, but localizes to the postsynaptic compartment. The… CONTINUE READING