Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins.

@article{Fukuda2001SynaptotagminlikeP1,
  title={Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins.},
  author={Mitsunori Fukuda and Katsuhiko Mikoshiba},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={281 5},
  pages={1226-33}
}
Synaptotagmins (Syt), rabphilin-3A, and Doc2 belong to a family of carboxyl terminal type (C-type) tandem C2 proteins and are thought to be involved in vesicular trafficking. We have cloned and characterized a novel family of C-type tandem C2 proteins, designated Slp1-3 (synaptotagmin-like protein 1-3). The Slp1-3 C2 domains show high homology to granuphilin-a C2 domains, but the amino-terminal domain of Slp1-3 does not contain any known protein motifs or a transmembrane domain. A subcellular… CONTINUE READING