Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia.

  title={Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia.},
  author={Shinichi Inoue and Akira Imamura and Yuji Okazaki and Hiroshi Yokota and Makoto Arai and Naoki Hayashi and Aizo Furukawa and Masanari Itokawa and M. Oishi},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  volume={144B 3},
Synaptotagmin XI (Syt11) is a member of the synaptotagmin family, which is localized in cells either in synaptic vesicles or the cellular membrane, and is known to act as a calcium sensor. The Syt11 gene is located on chromosome locus 1q21-q22, which was previously reported as a major susceptibility locus of familial schizophrenia. Here, we present evidence for an association between the number of 33-bp repeats in the promoter region of the Syt11 gene and schizophrenia. We found that the… CONTINUE READING
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