Synaptotagmin V and IX isoforms control Ca2+ -dependent insulin exocytosis.

  title={Synaptotagmin V and IX isoforms control Ca2+ -dependent insulin exocytosis.},
  author={Mariella Iezzi and Georgia Kouri and Mitsunori Fukuda and Claes B Wollheim},
  journal={Journal of cell science},
  volume={117 Pt 15},
Synaptotagmin (Syt) is involved in Ca2+ -regulated secretion and has been suggested to serve as a general Ca2+ sensor on the membrane of secretory vesicles in neuronal cells. Insulin exocytosis from the pancreatic beta-cell is an example of a Ca2+ -dependent secretory process. Previous studies have yielded conflicting results as to which Syt isoform is present on the secretory granules in the native beta-cell. Here we show by western blotting and RT-PCR analysis, the presence of both Syt V and… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 54 extracted citations


Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…