Synaptotagmin V and IX isoforms control Ca2+ -dependent insulin exocytosis.

@article{Iezzi2004SynaptotagminVA,
  title={Synaptotagmin V and IX isoforms control Ca2+ -dependent insulin exocytosis.},
  author={Mariella Iezzi and Georgia Kouri and Mitsunori Fukuda and Claes B Wollheim},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 15},
  pages={3119-27}
}
Synaptotagmin (Syt) is involved in Ca2+ -regulated secretion and has been suggested to serve as a general Ca2+ sensor on the membrane of secretory vesicles in neuronal cells. Insulin exocytosis from the pancreatic beta-cell is an example of a Ca2+ -dependent secretory process. Previous studies have yielded conflicting results as to which Syt isoform is present on the secretory granules in the native beta-cell. Here we show by western blotting and RT-PCR analysis, the presence of both Syt V and… CONTINUE READING

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