Synaptotagmin IV regulates glial glutamate release.

  title={Synaptotagmin IV regulates glial glutamate release.},
  author={Qi Zhang and Mitsunori Fukuda and Elisabeth J. Van Bockstaele and Olivier Pascual and Philip Haydon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 25},
Calcium-binding synaptotagmins (Syts) are membrane proteins that are conserved from nematode to human. Fifteen Syts (Syts I-XV) have been identified in mammalian species. Syt I has been well studied and is a candidate for the Ca(2+)-sensor that triggers evoked exocytosis underlying fast synaptic transmission. Whereas the functions of the other Syts are unclear, Syt IV is of particular interest because it is rapidly up-regulated after chronic depolarization or seizures, and because null… CONTINUE READING
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