Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells

@article{Ahras2006SynaptotagminII,
  title={Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells},
  author={Malika Ahras and G. P. Otto and Sharon A Tooze},
  journal={The Journal of Cell Biology},
  year={2006},
  volume={173},
  pages={241 - 251}
}
In neuroendocrine PC12 cells, immature secretory granules (ISGs) mature through homotypic fusion and membrane remodeling. We present evidence that the ISG-localized synaptotagmin IV (Syt IV) is involved in ISG maturation. Using an in vitro homotypic fusion assay, we show that the cytoplasmic domain (CD) of Syt IV, but not of Syt I, VII, or IX, inhibits ISG homotypic fusion. Moreover, Syt IV CD binds specifically to ISGs and not to mature secretory granules (MSGs), and Syt IV binds to syntaxin 6… CONTINUE READING

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