Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo

@article{Poskanzer2003SynaptotagminII,
  title={Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo},
  author={Kira Poskanzer and Kurt W. Marek and Sean T Sweeney and Graeme W Davis},
  journal={Nature},
  year={2003},
  volume={426},
  pages={559-563}
}
Neurotransmission requires a balance of synaptic vesicle exocytosis and endocytosis. Synaptotagmin I (Syt I) is widely regarded as the primary calcium sensor for synaptic vesicle exocytosis. Previous biochemical data suggest that Syt I may also function during synaptic vesicle endocytosis; however, ultrastructural analyses at synapses with impaired Syt I function have provided an indirect and conflicting view of the role of Syt I during synaptic vesicle endocytosis. Until now it has not been… CONTINUE READING
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