Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment

@article{Liu2014Synaptotagmin7F,
  title={Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment},
  author={Huisheng Liu and Hua Bai and Enfu Hui and Lu Yang and Chantell S. Evans and Zhao Wang and Sung E. Kwon and Edwin R. Chapman},
  journal={eLife},
  year={2014},
  volume={3}
}
Synaptotagmin (syt) 7 is one of three syt isoforms found in all metazoans; it is ubiquitously expressed, yet its function in neurons remains obscure. Here, we resolved Ca2+-dependent and Ca2+-independent synaptic vesicle (SV) replenishment pathways, and found that syt 7 plays a selective and critical role in the Ca2+-dependent pathway. Mutations that disrupt Ca2+-binding to syt 7 abolish this function, suggesting that syt 7 functions as a Ca2+-sensor for replenishment. The Ca2+-binding protein… Expand
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