Synaptotagmin 1 and SNAREs form a complex that is structurally heterogeneous.

  title={Synaptotagmin 1 and SNAREs form a complex that is structurally heterogeneous.},
  author={Alex L. Lai and Hao Wei Huang and Dawn Z. Herrick and Natalie Epp and David S Cafiso},
  journal={Journal of molecular biology},
  volume={405 3},
Synaptotagmin 1 (syt1) functions as a Ca(2+)-sensor for neuronal exocytosis. Here, site-directed spin labeling was used to examine the complex formed between a soluble fragment of syt1, which contains its two C2 domains, and the neuronal core soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex. Changes in electron paramagnetic resonance lineshape and accessibility for spin-labeled syt1 mutants indicate that in solution, the assembled core SNARE complex contacts… CONTINUE READING
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