Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells.

@article{Schonn2008Synaptotagmin1A,
  title={Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells.},
  author={Jean-S{\'e}bastien Schonn and Anton Maximov and Ye Lao and Thomas C S{\"u}dhof and Jakob Balslev S\orensen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 10},
  pages={3998-4003}
}
Synaptotagmin-1, the canonical isoform of the synaptotagmin family, is a Ca(2+) sensor for fast synchronous neurotransmitter release in forebrain neurons and chromaffin cells. Even though deletion of synaptotagmin-1 abolishes fast exocytosis in chromaffin cells, it reduces overall secretion by only 20% because of the persistence of slow exocytosis. Therefore, another Ca(2+) sensor dominates release in these cells. Synaptotagmin-7 has a higher Ca(2+) affinity and slower binding kinetics than… CONTINUE READING
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