Synaptotagmin: A Ca2+ sensor that triggers exocytosis?

  title={Synaptotagmin: A Ca2+ sensor that triggers exocytosis?},
  author={E. Chapman},
  journal={Nature Reviews Molecular Cell Biology},
  • E. Chapman
  • Published 2002
  • Chemistry, Medicine, Biology
  • Nature Reviews Molecular Cell Biology
  • It has been fifty years since the discovery that Ca2+ triggers the rapid exocytosis of neurotransmitters from neurons. One of the proteins that has a crucial role in this secretion event is synaptotagmin I, an abundant constituent of synaptic vesicles that binds Ca2+ ions through two C2 domains. These properties prompted the idea that synaptotagmin I might function as a Ca2+-sensor that triggers neurotransmitter release. So does synaptotagmin trigger exocytosis in a Ca2+-dependent manner, and… CONTINUE READING
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