Synaptosomal respiration: a potent indicator of veratridine-induced Na influx.

@article{Urenjak1991SynaptosomalRA,
  title={Synaptosomal respiration: a potent indicator of veratridine-induced Na influx.},
  author={J Urenjak and Frank Tegtmeier and A Beile and Saeed M. Khan and Thies Peters},
  journal={Pharmacology},
  year={1991},
  volume={43 1},
  pages={26-35}
}
Inhibition of the voltage-dependent Na channel by tetrodotoxin (5 mumol/l) decreased by about 86% the stimulation of the respiration of rat brain synaptosomes induced by veratridine (10 mumol/l). A similar effect was achieved by blocking Na(+)-K(+)-ATPase with ouabain (1 mmol/l). Pharmacological manipulations of Ca homeostasis suggested that the veratridine… CONTINUE READING