Synaptosomal glutamate release induced by the fraction Bc2 from the venom of the sea anemone Bunodosoma caissarum.

@article{Migues1999SynaptosomalGR,
  title={Synaptosomal glutamate release induced by the fraction Bc2 from the venom of the sea anemone Bunodosoma caissarum.},
  author={Paola Virginia Migues and Rodrigo Bainy Leal and Michela Mantovani and Mauro Nicolau and Nelson H. Gabilan},
  journal={Neuroreport},
  year={1999},
  volume={10 1},
  pages={
          67-70
        }
}
The effect of a fraction (Bc2) from the venom of the sea anemone Bunodosoma caissarum on [3H]glutamate release from rat cortical synaptosomes was investigated. Bc2 (2-20 microg/ml) provoked massive glutamate release without causing synaptosome disruption. Glutamate release stimulated by Bc2 was independent of extracellular Ca2+ and of voltage-sensitive Na+ channels, and it was completely abolished by the addition of sphingomyelin. No definitive evidence about the mechanism underlying the… CONTINUE READING

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