Synaptopodin regulates spine plasticity: mediation by calcium stores.

  title={Synaptopodin regulates spine plasticity: mediation by calcium stores.},
  author={Eduard Korkotian and Michael Frotscher and Menahem Segal},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={34 35},
The role of synaptopodin (SP), an actin-binding protein residing in dendritic spines, in synaptic plasticity was studied in dissociated cultures of hippocampus taken from control and SP knock-out (SPKO) mice. Unlike controls, SPKO cultures were unable to express changes in network activity or morphological plasticity after intense activation of their NMDA receptors. SPKO neurons were transfected with SP-GFP, such that the only SP resident in these neurons is the fluorescent species. The… CONTINUE READING