Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling

  title={Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling},
  author={Katsuhiko Asanuma and Etsuko Yanagida-Asanuma and Christian Faul and Yasuhiko Tomino and Kwanghee Kim and Peter H. Mundel},
  journal={Nature Cell Biology},
The Rho family of small GTPases (RhoA, Rac1 and Cdc42) controls signal-transduction pathways that influence many aspects of cell behaviour, including cytoskeletal dynamics. At the leading edge, Rac1 and Cdc42 promote cell motility through the formation of lamellipodia and filopodia, respectively. On the contrary, RhoA promotes the formation of contractile actin–myosin-containing stress fibres in the cell body and at the rear. Here, we identify synaptopodin, an actin-associated protein, as a… CONTINUE READING
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