Synaptopodin couples epithelial contractility to α-actinin-4–dependent junction maturation

  title={Synaptopodin couples epithelial contractility to α-actinin-4–dependent junction maturation},
  author={Nivetha Kannan and Vivian W Tang},
  booktitle={The Journal of cell biology},
The epithelial junction experiences mechanical force exerted by endogenous actomyosin activities and from interactions with neighboring cells. We hypothesize that tension generated at cell-cell adhesive contacts contributes to the maturation and assembly of the junctional complex. To test our hypothesis, we used a hydraulic apparatus that can apply mechanical force to intercellular junction in a confluent monolayer of cells. We found that mechanical force induces α-actinin-4 and actin… CONTINUE READING
6 Citations
288 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 288 references

The C

  • A. Stetak, A. Hajnal.
  • elegans MAGI-1 protein is a novel component of…
  • 2011
Highly Influential
7 Excerpts

Similar Papers

Loading similar papers…