Synaptophysin Regulates the Kinetics of Synaptic Vesicle Endocytosis in Central Neurons

@article{Kwon2011SynaptophysinRT,
  title={Synaptophysin Regulates the Kinetics of Synaptic Vesicle Endocytosis in Central Neurons},
  author={Sung E. Kwon and Edwin R. Chapman},
  journal={Neuron},
  year={2011},
  volume={70},
  pages={847-854}
}
Despite being the most abundant synaptic vesicle membrane protein, the function of synaptophysin remains enigmatic. For example, synaptic transmission was reported to be completely normal in synaptophysin knockout mice; however, direct experiments to monitor the synaptic vesicle cycle have not been carried out. Here, using optical imaging and electrophysiological experiments, we demonstrate that synaptophysin is required for kinetically efficient endocytosis of synaptic vesicles in cultured… Expand
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