Synaptophysin: a marker protein for neuroendocrine cells and neoplasms.

  title={Synaptophysin: a marker protein for neuroendocrine cells and neoplasms.},
  author={Bertram J Wiedenmann and Werner Franke and Caecilia Kuhn and Roland Moll and Victor E. Gould},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={83 10},
Synaptophysin is an integral membrane glycoprotein (Mr 38,000) that occurs in presynaptic vesicles of neurons and in similar vesicles of the adrenal medulla. By using a monoclonal antibody to this protein (SY38), we have found, by immunohistochemistry and immunoblotting, that an identical or similar protein is also expressed in neuroendocrine tumors of neural type, such as pheochromocytomas and paragangliomas. In addition, this protein occurs in certain neuroendocrine epithelial cells, such as… CONTINUE READING


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