Synaptopathies: diseases of the synaptome.

@article{Grant2012SynaptopathiesDO,
  title={Synaptopathies: diseases of the synaptome.},
  author={Seth G. N. Grant},
  journal={Current opinion in neurobiology},
  year={2012},
  volume={22 3},
  pages={522-9}
}
The human synapse proteome is a highly complex collection of proteins that is disrupted by hundreds of gene mutations causing over 100 brain diseases. These synaptic diseases, or synaptopathies, cause major psychiatric, neurological and childhood developmental disorders through mendelian and complex genetic mechanisms. The human postsynaptic proteome and its core signaling complexes built by the assembly of receptors and enzymes around Membrane Associated Guanylate Kinase (MAGUK) scaffold… CONTINUE READING