Synaptonemal complex antigen location and conservation

  title={Synaptonemal complex antigen location and conservation},
  author={Peter B. Moens and Christa Heyting and Axel J. J. Dietrich and W van Raamsdonk and Q Chen},
  journal={The Journal of Cell Biology},
  pages={93 - 103}
The axial cores of chromosomes in the meiotic prophase nuclei of most sexually reproducing organisms play a pivotal role in the arrangement of chromatin, in the synapsis of homologous chromosomes, in the process of genetic recombination, and in the disjunction of chromosomes. We report an immunogold analysis of the axial cores and the synaptonemal complexes (SC) using two mouse monoclonal antibodies raised against isolated rat SCs. In Western blots of purified SCs, antibody II52F10 recognizes a… CONTINUE READING