Synaptonemal Complex-Dependent Centromeric Clustering and the Initiation of Synapsis in Drosophila Oocytes

@article{Takeo2011SynaptonemalCC,
  title={Synaptonemal Complex-Dependent Centromeric Clustering and the Initiation of Synapsis in Drosophila Oocytes},
  author={Satomi Takeo and Cathleen M. Lake and Eurico Morais-de-S{\'a} and Claudio E Sunkel and R. Scott Hawley},
  journal={Current Biology},
  year={2011},
  volume={21},
  pages={1845-1851}
}
The pairing of homologous chromosomes and the intimate synapsis of the paired homologs by the synaptonemal complex (SC) are essential for subsequent meiotic processes including recombination and chromosome segregation. Here we show that the centromere clustering plays an important role in initiating homolog synapsis during meiosis in Drosophila females. Although centromeres are not clustered prior to the onset of meiosis, all four pairs of centromeres are actively clustered into one or two… CONTINUE READING
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