Synaptonemal Complex Components Persist at Centromeres and Are Required for Homologous Centromere Pairing in Mouse Spermatocytes

@inproceedings{Bisig2012SynaptonemalCC,
  title={Synaptonemal Complex Components Persist at Centromeres and Are Required for Homologous Centromere Pairing in Mouse Spermatocytes},
  author={Carlos Gaston Bisig and Michel F. Guiraldelli and Anna Kouznetsova and Harry Scherthan and Christer H{\"o}{\"o}g and Dean S Dawson and Roberto J Pezza},
  booktitle={PLoS genetics},
  year={2012}
}
Recent studies in simple model organisms have shown that centromere pairing is important for ensuring high-fidelity meiotic chromosome segregation. However, this process and the mechanisms regulating it in higher eukaryotes are unknown. Here we present the first detailed study of meiotic centromere pairing in mouse spermatogenesis and link it with key events of the G2/metaphase I transition. In mouse we observed no evidence of the persistent coupling of centromeres that has been observed in… CONTINUE READING

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The synaptonemal complex protein, Zip1, promotes the segregation of nonexchange chromosomes at meiosis I.

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