Synaptojanin 1 contributes to maintaining the stability of GABAergic transmission in primary cultures of cortical neurons.

@article{Luthi2001Synaptojanin1C,
  title={Synaptojanin 1 contributes to maintaining the stability of GABAergic transmission in primary cultures of cortical neurons.},
  author={A Luthi and Gilbert di Paolo and Ottavio Cremona and Laurie Daniell and Pietro De Camilli and David A. McCormick},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 23},
  pages={9101-11}
}
Inhibitory synapses in the CNS can exhibit a considerable stability of neurotransmission over prolonged periods of high-frequency stimulation. Previously, we showed that synaptojanin 1 (SJ1), a presynaptic polyphosphoinositide phosphatase, is required for normal synaptic vesicle recycling (Cremona et al., 1999). We asked whether the stability of inhibitory synaptic responses was dependent on SJ1. Whole-cell patch-clamp recordings of unitary IPSCs were obtained in primary cortical cultures… CONTINUE READING