Synaptogyrin-dependent modulation of synaptic neurotransmission in Caenorhabditis elegans

  title={Synaptogyrin-dependent modulation of synaptic neurotransmission in Caenorhabditis elegans
  author={Christian Abraham and Lin Bai and Rudolf E. Leube},
Abnormal Synaptic Vesicle Biogenesis in Drosophila Synaptogyrin Mutants
It is demonstrated that Drosophila synaptogyrin plays a modulatory role in synaptic vesicle biogenesis at larval neuromuscular junctions and modulates the synapticvesicle exo-endocytic cycle and is required for the proper biogenesis of synaptic vESicles at nerve terminals.
Neuropeptidergic control of synaptic vesicle filling and behavior in the nematode "Caenorhabditis elegans"
This thesis reports on the results obtained by expression photoactivatable adenylyl cyclase from Beggiatoa spp. (bPAC) in cholinergic neurons from Caenorhabditis elegans (C. elegans) and the
Synaptophysin Is Required for Synaptobrevin Retrieval during Synaptic Vesicle Endocytosis
A specific and selective requirement for synaptophysin is identified in the retrieval of the pH-sensitive fluorescent reporter sybII-pHluorin from the plasma membrane during endocytosis, suggesting that their interaction may act as an adjustable regulator of SV retrieval efficiency.
The presynaptic machinery at the synapse of C. elegans
Research on the major group of synaptic proteins, involved in the presynaptic machinery in C. elegans is reviewed, showing a strong conservation between higher organisms and highlighting how the nematode can be used as an informative tool for dissecting synaptic components, based on a simple nervous system organization.
The iTRAPs: Guardians of Synaptic Vesicle Cargo Retrieval During Endocytosis
This review summarizes current knowledge regarding the retrieval mechanisms for both sybII and synaptotagmin-1 during endocytosis and defines and set criteria for a new functional group of SV molecules that facilitate the retrieval of their interaction partners.
Exocytosis and synaptic vesicle function.
  • O. Shin
  • Biology
    Comprehensive Physiology
  • 2014
Different SNARE protein isoforms and membrane lipids, which interact with SyT1 with various affinities, are capable of regulating the efficacy of Syt1-mediated exocytosis.
Ontogeny of a synaptophysin-mediated GABA transmission mechanism from the ciliary band-associated strand to the ciliary band during the development of the sea urchin Hemicentrotus pulcherrimus
The synaptic transmission mechanism of GABA is examined by focusing on the spatiotemporal expression pattern of synaptophysin (Syp), a synaptic vesicle glycoprotein in the sea urchin, which encodes a 266-amino acid protein with possibly 4 transmembrane domains.
The ontogeny of synaptophysin expression patterns on the GABAergic ciliary band-associated strand during larval development of the sea urchin, Hemicentrotus pulcherrimus A. Agassiz, 1864
The present study indicated close localization of GABA and Syp in the puncta of the CBAS and that, for the first time in the sea urchin nervous system, implicates the Syp-mediated efferent GABA transmission from theCBAS to the CB.
Synaptogyrin-2 Promotes Replication of a Novel Tick-borne Bunyavirus through Interacting with Viral Nonstructural Protein NSs*
It is hypothesized that synaptogyrin-2 is essential to promoting the formation of the IBs to become virus factories for viral RNA replication through its interaction with NSs, which were reconstructed from lipid droplets into large structures in infection.
Inactivation of GABAA receptor is related to heat shock stress response in organism model Caenorhabditis elegans
The results of the present study suggest that oxidative stress, through either H2O2 exposure or application of heat shock, inactivates the GABAergic system, which subsequently would affect the oxidative stress response, perhaps by enhancing the activity of transcription factors DAF-16 and HSF-1, both regulated by the IIS pathway and related to hsp-16.2 expression.


Synaptic Transmission Deficits in Caenorhabditis elegansSynaptobrevin Mutants
It is demonstrated that synaptobrevin is essential for viability and is required for functional synaptic transmission, however, the analysis suggests that transmitter release is not completely eliminated by removal of either one or both v-SNAREs.
Synaptic tetraspan vesicle membrane proteins are conserved but not needed for synaptogenesis and neuronal function in Caenorhabditis elegans.
It is concluded that TVPs are not needed for the basic neuronal machinery and instead may contribute to subtle higher order functions.
A conserved mechanism of synaptogyrin localization.
This study suggests that the mechanisms for synaptogyrin localization are likely to be conserved from C. elegans to vertebrates.
Synaptogyrins Regulate Ca2+-dependent Exocytosis in PC12 Cells*
The results suggest that synaptogyrins are conserved components of the exocytotic apparatus, which function as regulators of Ca2+-dependent exocyTosis.
Mice lacking synaptophysin reproduce and form typical synaptic vesicles
Immunofluorescence microscopy of several neuronal and neuroendocrine tissues showed that overall tissue architecture was maintained in the absence of synaptophysin, and that the distribution of other synaptic vesicle components was not visibly affected.
Characterization of synaptogyrin 3 as a new synaptic vesicle protein
The data indicate that neuronal synaptogyrins are differentially expressed protein isoforms that may represent functionally distinct populations of synapses and/or synaptic vesicles.
Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine.
It is concluded that synaptophysin selectively interacts with synaptobrevin in a complex which excludes the t‐SNAP receptors syntaxin I and SNAP‐25, suggesting a role for synaptophysicalin in the control of exocytosis.
Activity-dependent changes of the presynaptic synaptophysin-synaptobrevin complex in adult rat brain.
It is shown that the synaptophysin-synaptobrevin complex is increased in adult rat brain after repeated synaptic hyperactivity in the kindling model of epilepsy, and this interaction is concluded to be involved in activity-dependent plastic changes inadult rat brain.
Structure of synaptogyrin (p29) defines novel synaptic vesicle protein
Cloned and sequenced the cDNA encoding synaptogyrin, and the sequence predicts a protein with a molecular mass of 25,900 D with four membrane- spanning domains that was confirmed by limited proteolysis using domain-specific antibodies and significant overlap with transferrin staining was observed.