Synaptogyrin-dependent modulation of synaptic neurotransmission in Caenorhabditis elegans 

@article{Abraham2011SynaptogyrindependentMO,
  title={Synaptogyrin-dependent modulation of synaptic neurotransmission in Caenorhabditis elegans
},
  author={Christian Abraham and Lin Bai and Rudolf E. Leube},
  journal={Neuroscience},
  year={2011},
  volume={190},
  pages={75-88}
}
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The presynaptic machinery at the synapse of C. elegans
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Research on the major group of synaptic proteins, involved in the presynaptic machinery in C. elegans is reviewed, showing a strong conservation between higher organisms and highlighting how the nematode can be used as an informative tool for dissecting synaptic components, based on a simple nervous system organization.
The iTRAPs: Guardians of Synaptic Vesicle Cargo Retrieval During Endocytosis
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Exocytosis and synaptic vesicle function.
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Different SNARE protein isoforms and membrane lipids, which interact with SyT1 with various affinities, are capable of regulating the efficacy of Syt1-mediated exocytosis.
Ontogeny of a synaptophysin-mediated GABA transmission mechanism from the ciliary band-associated strand to the ciliary band during the development of the sea urchin Hemicentrotus pulcherrimus
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The synaptic transmission mechanism of GABA is examined by focusing on the spatiotemporal expression pattern of synaptophysin (Syp), a synaptic vesicle glycoprotein in the sea urchin, which encodes a 266-amino acid protein with possibly 4 transmembrane domains.
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The present study indicated close localization of GABA and Syp in the puncta of the CBAS and that, for the first time in the sea urchin nervous system, implicates the Syp-mediated efferent GABA transmission from theCBAS to the CB.
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Inactivation of GABAA receptor is related to heat shock stress response in organism model Caenorhabditis elegans
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The results of the present study suggest that oxidative stress, through either H2O2 exposure or application of heat shock, inactivates the GABAergic system, which subsequently would affect the oxidative stress response, perhaps by enhancing the activity of transcription factors DAF-16 and HSF-1, both regulated by the IIS pathway and related to hsp-16.2 expression.
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It is demonstrated that synaptobrevin is essential for viability and is required for functional synaptic transmission, however, the analysis suggests that transmitter release is not completely eliminated by removal of either one or both v-SNAREs.
Synaptic tetraspan vesicle membrane proteins are conserved but not needed for synaptogenesis and neuronal function in Caenorhabditis elegans.
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This study suggests that the mechanisms for synaptogyrin localization are likely to be conserved from C. elegans to vertebrates.
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Immunofluorescence microscopy of several neuronal and neuroendocrine tissues showed that overall tissue architecture was maintained in the absence of synaptophysin, and that the distribution of other synaptic vesicle components was not visibly affected.
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TLDR
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TLDR
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TLDR
Cloned and sequenced the cDNA encoding synaptogyrin, and the sequence predicts a protein with a molecular mass of 25,900 D with four membrane- spanning domains that was confirmed by limited proteolysis using domain-specific antibodies and significant overlap with transferrin staining was observed.
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