Synaptogenesis in visual cortex of normal and preterm monkeys: evidence for intrinsic regulation of synaptic overproduction.

@article{Bourgeois1989SynaptogenesisIV,
  title={Synaptogenesis in visual cortex of normal and preterm monkeys: evidence for intrinsic regulation of synaptic overproduction.},
  author={J. P. Bourgeois and Pawel J. Jastreboff and Pasko Raki{\'c}},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 11},
  pages={4297-301}
}
We used quantitative electron microscopy to determine the effect of precocious visual experience on the time course, magnitude, and pattern of perinatal synaptic overproduction in the primary visual cortex of the rhesus monkey. Fetuses were delivered by caesarean section 3 weeks before term, exposed to normal light intensity and day/night cycles, and killed within the first postnatal month, together with age-matched controls that were delivered at term. We found that premature visual… CONTINUE READING