Synaptically activated burst-generating conductances may underlie a group-pacemaker mechanism for respiratory rhythm generation in mammals.

@article{Negro2010SynapticallyAB,
  title={Synaptically activated burst-generating conductances may underlie a group-pacemaker mechanism for respiratory rhythm generation in mammals.},
  author={Christopher A Del Negro and John A Hayes and Ryland W Pace and Benjamin Brush and Ryoichi Teruyama and Jack L Feldman},
  journal={Progress in brain research},
  year={2010},
  volume={187},
  pages={111-36}
}
Breathing, chewing, and walking are critical life-sustaining behaviors in mammals that consist essentially of simple rhythmic movements. Breathing movements in particular involve the diaphragm, thorax, and airways but emanate from a network in the lower brain stem. This network can be studied in reduced preparations in vitro and using simplified mathematical models that make testable predictions. An iterative approach that employs both in vitro and in silico models argues against canonical… CONTINUE READING

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Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P.

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