Synaptic weight set by Munc13-1 supramolecular assemblies

  title={Synaptic weight set by Munc13-1 supramolecular assemblies},
  author={Hirokazu Sakamoto and Tetsuroh Ariyoshi and Naoya Kimpara and Kohtaroh Sugao and Isamu Taiko and Kenji Takikawa and Daisuke Asanuma and Shigeyuki Namiki and Kenzo Hirose},
  journal={Nature Neuroscience},
The weight of synaptic connections, which is controlled not only postsynaptically but also presynaptically, is a key determinant in neuronal network dynamics. The mechanisms controlling synaptic weight, especially on the presynaptic side, remain elusive. Using single-synapse imaging of the neurotransmitter glutamate combined with super-resolution imaging of presynaptic proteins, we identify a presynaptic mechanism for setting weight in central glutamatergic synapses. In the presynaptic terminal… CONTINUE READING
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