Synaptic vulnerability in neurodegenerative disease.

  title={Synaptic vulnerability in neurodegenerative disease.},
  author={Thomas M Wishart and Simon H Parson and Thomas H Gillingwater},
  journal={Journal of neuropathology and experimental neurology},
  volume={65 8},
Recent developments in our understanding of the pathophysiological mechanisms underlying degeneration in both the central and peripheral nervous systems have highlighted the critical role that synapses play in the instigation and progression of neuronal loss. In fact, several lines of evidence suggest that previous attempts to delay the onset and progression of clinical symptoms in a broad range of neurodegenerative diseases may have been unsuccessful as a result of a failure to protect… CONTINUE READING


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