Synaptic vesicles contain an ATP-dependent proton pump and show 'knob-like' protrusions on their surface.

@article{Stadler1984SynapticVC,
  title={Synaptic vesicles contain an ATP-dependent proton pump and show 'knob-like' protrusions on their surface.},
  author={H W Stadler and S. Tsukita},
  journal={The EMBO journal},
  year={1984},
  volume={3 13},
  pages={
          3333-7
        }
}
Synaptic vesicles from guinea pig brain were highly purified by chromatography on Sephacryl S 1000. They were associated with a Mg-ATPase which could be solubilized with dichloromethane from vesicle membranes, and which elutes upon gel filtration with a mol. wt. approximately 300 kd. Vesicles accumulate [14C]methylamine in the presence of external ATP, indicating an ATP-dependent proton pump. Electron microscopy using a quick freeze, deep etch, rotary shadowing technique showed characteristic… CONTINUE READING

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