Synaptic vesicles: test for a role in presynaptic calcium regulation.

  title={Synaptic vesicles: test for a role in presynaptic calcium regulation.},
  author={Greg T. Macleod and Leo Marin and Milton P. Charlton and Harold L. Atwood},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={24 10},
Membrane-bound organelles such as mitochondria and the endoplasmic reticulum play an important role in neuronal Ca(2+) homeostasis. Synaptic vesicles (SVs), the organelles responsible for exocytosis of neurotransmitters, occupy more of the volume of presynaptic nerve terminals than any other organelle and, under some conditions, can accumulate Ca(2+). They are also closely associated with voltage-gated Ca(2+) channels (VGCCs) that trigger transmitter release by admitting Ca(2+) into the nerve… CONTINUE READING