Synaptic vesicle transport and synaptic membrane transporter sites in excitatory amino acid nerve terminals in Alzheimer disease

@article{Westphalen2003SynapticVT,
  title={Synaptic vesicle transport and synaptic membrane transporter sites in excitatory amino acid nerve terminals in Alzheimer disease},
  author={Robert Ian Westphalen and Heather L. Scott and Peter Ronald Dodd},
  journal={Journal of Neural Transmission},
  year={2003},
  volume={110},
  pages={1013-1027}
}
 The apparent l-[3H]glutamate uptake rate (v′) was measured in synaptic vesicles isolated from cerebral cortex synaptosomes prepared from autopsied Alzheimer and non-Alzheimer dementia cases, and age-matched controls. The initial synaptosome preparations exhibited similar densities of d-[3H]aspartate membrane binding sites (BMAX values) in the three groups. In control brain the temporal cortex d-[3H]aspartate BMAX was 132% of that in motor cortex, parallel with the l-[3H]glutamate v′ values… CONTINUE READING