Synaptic vesicle tethering and the CaV2.2 distal C-terminal

@article{Wong2014SynapticVT,
  title={Synaptic vesicle tethering and the CaV2.2 distal C-terminal},
  author={Fiona K. Wong and Arup R. Nath and R. C. Chen and Sabiha R. Gardezi and Q. Li and E. F. Stanley},
  journal={Frontiers in Cellular Neuroscience},
  year={2014},
  volume={8}
}
Evidence that synaptic vesicles (SVs) can be gated by a single voltage sensitive calcium channel (CaV2.2) predict a molecular linking mechanism or “tether” (Stanley, 1993). Recent studies have proposed that the SV binds to the distal C-terminal on the CaV2.2 calcium channel (Kaeser et al., 2011; Wong et al., 2013) while genetic analysis proposed a double tether mechanism via RIM: directly to the C terminus PDZ ligand domain or indirectly via a more proximal proline rich site (Kaeser et al… Expand
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Characterization of a Synaptic Vesicle Binding Motif on the Distal CaV2.2 Channel C-terminal
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Molecular Characterization of an SV Capture Site in the Mid-Region of the Presynaptic CaV2.1 Calcium Channel C-Terminal
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The Calcium Channel C-Terminal and Synaptic Vesicle Tethering: Analysis by Immuno-Nanogold Localization
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On Cryoloading: A Novel Technique used for the Functional Analysis of CAV2.2 - Synaptic Vesicle Tethering
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A novel region in the CaV2.1 α1 subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone
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Ultrastructural Analysis of the Role of Voltage-Gated Calcium Channel Intracellular Domains in Synaptic Vesicle Tethering at Presynaptic Terminals
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Mobility of Calcium Channels in the Presynaptic Membrane
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C-terminal splice variants of P/Q-type Ca2+ channel CaV2.1 α1 subunits are differentially regulated by Rab3-interacting molecule proteins
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Existence of P/Q-type Calcium Channels in Chicken Presynaptic Nerve Terminals?
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References

SHOWING 1-10 OF 67 REFERENCES
Synaptic vesicle capture by CaV2.2 calcium channels
  • 21
Inter-channel scaffolding of presynaptic CaV2.2 via the C terminal PDZ ligand domain
  • 7
  • PDF
Rab3a interacting molecule (RIM) and the tethering of pre‐synaptic transmitter release site‐associated CaV2.2 calcium channels
  • 28
Association of Neuronal Calcium Channels with Modular Adaptor Proteins*
  • 312
  • Highly Influential
  • PDF
A proteomic screen for presynaptic terminal N-type calcium channel (CaV2.2) binding partners.
  • 55
  • PDF
RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction
  • 435
  • Highly Influential
  • PDF
Synaptic Targeting of N-Type Calcium Channels in Hippocampal Neurons
  • 184
  • PDF
N type Ca2+ channels and RIM scaffold protein covary at the presynaptic transmitter release face but are components of independent protein complexes
  • 42
Long splice variant N type calcium channels are clustered at presynaptic transmitter release sites without modular adaptor proteins
  • 32
RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release
  • 223
  • Highly Influential
  • PDF
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1
2
3
4
5
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