Synaptic vesicle tethering and the CaV2.2 distal C-terminal

@article{Wong2014SynapticVT,
  title={Synaptic vesicle tethering and the CaV2.2 distal C-terminal},
  author={Fiona K. Wong and Arup R. Nath and R. C. Chen and Sabiha R. Gardezi and Q. Li and E. F. Stanley},
  journal={Frontiers in Cellular Neuroscience},
  year={2014},
  volume={8}
}
Evidence that synaptic vesicles (SVs) can be gated by a single voltage sensitive calcium channel (CaV2.2) predict a molecular linking mechanism or “tether” (Stanley, 1993). Recent studies have proposed that the SV binds to the distal C-terminal on the CaV2.2 calcium channel (Kaeser et al., 2011; Wong et al., 2013) while genetic analysis proposed a double tether mechanism via RIM: directly to the C terminus PDZ ligand domain or indirectly via a more proximal proline rich site (Kaeser et al… Expand
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