Synaptic vesicle tethering and the CaV2.2 distal C-terminal

@inproceedings{Wong2014SynapticVT,
  title={Synaptic vesicle tethering and the CaV2.2 distal C-terminal},
  author={Fiona K.Y Wong and Arup R. Nath and Robert Chien-Chung Chen and Sabiha R. Gardezi and Qi Li and Elise F. Stanley},
  booktitle={Front. Cell. Neurosci.},
  year={2014}
}

• Fiona K.Y Wong, Arup R. Nath, +3 authors Elise F. Stanley
• Published 2014 in Front. Cell. Neurosci.
• DOI:10.3389/fncel.2014.00071

Evidence that synaptic vesicles (SVs) can be gated by a single voltage sensitive calcium channel (CaV2.2) predict a molecular linking mechanism or "tether" (Stanley, 1993). Recent studies have proposed that the SV binds to the distal C-terminal on the CaV2.2 calcium channel (Kaeser et al., 2011; Wong et al., 2013) while genetic analysis proposed a double tether mechanism via RIM: directly to the C terminus PDZ ligand domain or indirectly via a more proximal proline rich site (Kaeser et al… CONTINUE READING

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