Synaptic vesicle recycling at CNS snapses without AP-2.

  title={Synaptic vesicle recycling at CNS snapses without AP-2.},
  author={Sung Hyun Kim and Timothy A Ryan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={29 12},
Synaptic vesicles (SVs) are composed of approximately 10 types of transmembrane proteins that must be recycled after exocytosis of neurotransmitter. The mechanisms for resorting these proteins into synaptic vesicles once incorporated into the plasma membrane after exocytosis are poorly understood. The adaptor complex AP-2 is the major clathrin-associated adaptor for cargo recognition at the plasma membrane. Here, we have investigated its role in synaptic vesicle endocytosis. shRNA-mediated… CONTINUE READING
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