Synaptic vesicle protein 2B is expressed in podocyte, and its expression is altered in proteinuric glomeruli.

@article{Miyauchi2006SynapticVP,
  title={Synaptic vesicle protein 2B is expressed in podocyte, and its expression is altered in proteinuric glomeruli.},
  author={Naoko Miyauchi and Akira Saito and Tamaki Karasawa and Yutaka Harita and Koichi Suzuki and Hiroko Koike and Gi Dong Han and Fujio Shimizu and Hiroshi Kawachi},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2006},
  volume={17 10},
  pages={
          2748-59
        }
}
Synaptic vesicle protein 2B (SV2B) was identified by the subtraction hybridization technique as a molecule of which mRNA expression was decreased in puromycin aminonucleoside (PAN) nephropathy by glomerular cDNA subtraction assay. The expression of SV2B was detected in glomerular lysate with Western blot analysis. Dual-labeling immunofluorescence studies with glomerular cell markers demonstrated that SV2B is expressed in glomerular visceral epithelial cells (podocytes). The expression of SV2B… 
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Neurexin-1, a presynaptic adhesion molecule, localizes at the slit diaphragm of the glomerular podocytes in kidneys.
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It is proposed that IP-10, SV2B, ephrin B1 and the receptors of angiotensin II type 2 receptor-mediated action enhanced the expression of nephrin and could be novel therapeutic targets for proteinuria.
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The results suggest that the SV2 isoforms are functional molecules of (pre)odontoblasts which may be involved in vesicle transport.
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TLDR
In this article, new insights into these molecules and the pathogenic roles of the dysfunction of these molecules were introduced, and a strategy for the establishment of a novel therapy for proteinuria was proposed.
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TLDR
Progress in the knowledge of the structure and function of glomerular podocytes should result in the elucidation of the pathogenesis of nephrotic proteinuria in commonly acquired proteinuric diseases and should pave the way to new therapeutic approaches.
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TLDR
The slit diaphragm bridging the neighboring foot processes functions as a final barrier of glomerular capillary wall for preventing the leak of plasma proteins into primary urine, and it is found that synaptic vesicle protein 2B, ephrin-B1 and neurexin were already downregulated at the early stage of puromycin aminonucleoside nephropathy.
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