Synaptic transmission modulates while non-synaptic processes govern the transition from pre-ictal to seizure activity in vitro

It is well established that non-synaptic mechanisms can generate electrographic seizures after blockade of synaptic function. We investigated the interaction of intact synaptic activity with nonsynaptic mechanisms in the isolated CA1 region of rat hippocampal slices using the “elevated-K” model of epilepsy. Elevated K ictal bursts share waveform features… CONTINUE READING