Synaptic transmission blockade increases plasminogen activator activity in mouse skeletal muscle poisoned with botulinum toxin type A.


Experimental denervation, either by nerve crush or axotomy, leads to a dramatic increase in muscle plasminogen activator (PA) activity, suggesting a regulation of muscle PA levels by some neural influence (Festoff et al., 1986, J. Cell Biol., 103:1415-1421; Hantaï et al., 1990, Proc. Natl. Acad. Sci. U.S.A., 87:2926-2930). The Botulinum toxin (BoTx) type A… (More)


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