Synaptic transmission at nicotinic acetylcholine receptors in rat hippocampal organotypic cultures and slices.

@article{Hefft1999SynapticTA,
  title={Synaptic transmission at nicotinic acetylcholine receptors in rat hippocampal organotypic cultures and slices.},
  author={S Hefft and S Hulo and Daniel Bertrand and Dominique Muller},
  journal={The Journal of physiology},
  year={1999},
  volume={515 ( Pt 3)},
  pages={769-76}
}
1. Whole-cell clamp recordings of the compound synaptic current elicited by afferent stimulation of Schaffer collaterals showed that blockade of the NMDA, AMPA and GABAA receptor-mediated components by 6-nitro-7-sulphamoyl- benzo(f)quinoxaline-2,3-dione (NBQX), 3-((R)-2-carboxypiperazine-4-yl)propyl-1-phosphonate (R-CPP) and picrotoxin, respectively, left a small residual current in 39 out of 41 CA1 pyramidal neurones in organotypic cultures and 9 out of 16 CA1 cells in acutely prepared slices… CONTINUE READING
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