Synaptic targeting by A oligomers ( ADDLS ) as a basis for memory loss in early Alzheimer ’ s disease

@inproceedings{Klein2006SynapticTB,
  title={Synaptic targeting by A oligomers ( ADDLS ) as a basis for memory loss in early Alzheimer ’ s disease},
  author={William L. Klein},
  year={2006}
}
bstract Early diagnosis and treatment of Alzheimer’s Disease (AD) ultimately will require identification of its pathogenic mechanism. Such a mechanism must explain the hallmark of early AD—a profound inability to form new memories. For many years, the most promising hypothesis maintained that memory failure derived from neuron death induced by insoluble deposits of amyloid fibrils. Newer findings, however, suggest that memory loss, especially in early AD, may be a failure in synaptic plasticity… CONTINUE READING
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