Synaptic targeting and localization of Discs-large is a stepwise process controlled by different domains of the protein

@article{Thomas2000SynapticTA,
  title={Synaptic targeting and localization of Discs-large is a stepwise process controlled by different domains of the protein},
  author={Ulrich Thomas and Susanne Ebitsch and Michael Gorczyca and Young Ho Koh and Colleen Hough and Daniel Woods and Eckart D. Gundelfinger and Vivian Budnik},
  journal={Current Biology},
  year={2000},
  volume={10},
  pages={1108-1117}
}
BACKGROUND Membrane-associated guanylate kinases (MAGUKs) assemble ion channels, cell-adhesion molecules and components of second messenger cascades into synapses, and are therefore potentially important for co-ordinating synaptic strength and structure. Here, we have examined the targeting of the Drosophila MAGUK Discs-large (DLG) to larval neuromuscular junctions. RESULTS During development, DLG was first found associated with the muscle subcortical compartment and plasma membrane, and… CONTINUE READING

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