Synaptic tagging and long-term potentiation

  title={Synaptic tagging and long-term potentiation},
  author={U. Frey and R. Morris},
  • U. Frey, R. Morris
  • Published 1997
  • Biology, Medicine
  • Nature
  • Repeated stimulation of hippocampal neurons can induce an immediate and prolonged increase in synaptic strength that is called long-term potentiation (LTP)—the primary cellular model of memory in the mammalian brain1. An early phase of LTP (lasting less than three hours) can be dissociated from late-phase LTP by using inhibitors of transcription and translation2–8. Because protein synthesis occurs mainly in the cell body9–12, whereas LTP is input-specific, the question arises of how the synapse… CONTINUE READING
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