Synaptic tagging and long-term potentiation

@article{Frey1997SynapticTA,
  title={Synaptic tagging and long-term potentiation},
  author={Uwe Frey and Richard G. M. Morris},
  journal={Nature},
  year={1997},
  volume={385},
  pages={533-536}
}
Repeated stimulation of hippocampal neurons can induce an immediate and prolonged increase in synaptic strength that is called long-term potentiation (LTP)—the primary cellular model of memory in the mammalian brain1. An early phase of LTP (lasting less than three hours) can be dissociated from late-phase LTP by using inhibitors of transcription and translation2–8. Because protein synthesis occurs mainly in the cell body9–12, whereas LTP is input-specific, the question arises of how the synapse… Expand
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TLDR
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  • Biology, Medicine
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TLDR
A critical review of the literature relating to the role of gene expression in hippocampal LTP and a discussion of recent work on the subject will be presented. Expand
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