Synaptic tagging and long-term potentiation

  title={Synaptic tagging and long-term potentiation},
  author={Uwe Frey and Richard G. M. Morris},
Repeated stimulation of hippocampal neurons can induce an immediate and prolonged increase in synaptic strength that is called long-term potentiation (LTP)—the primary cellular model of memory in the mammalian brain1. An early phase of LTP (lasting less than three hours) can be dissociated from late-phase LTP by using inhibitors of transcription and translation2–8. Because protein synthesis occurs mainly in the cell body9–12, whereas LTP is input-specific, the question arises of how the synapse… 

Synaptic capture-mediated long-lasting long-term potentiation is strongly dependent on mRNA translation

It is found that anisomycin (25 μM), a translational inhibitor, impaired the strong stimulation-induced L-LTP more severely when the drug was applied during the whole experiment than when delivered only around the induction period.

Synaptic tagging and capture in the living rat

The past and future activity of neurons plays a critical role in determining the persistence of synaptic changes in the living animal, thus providing a bridge between cellular studies of protein-synthesis-dependent synaptic potentiation and behavioural studies of memory persistence.

Tag-Trigger-Consolidation: A Model of Early and Late Long-Term-Potentiation and Depression

A mathematical model is presented that describes the induction of long-term potentiation and depression (LTP/LTD) during the early phase of synaptic plasticity, the setting of synaptic tags, a trigger process for protein synthesis, and a slow transition leading to synaptic consolidation during the late phase ofaptic plasticity.

Gene Expression in Hippocampal Long-Term Potentiation

  • S. DudekR. Fields
  • Biology
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 1999
A critical review of the literature relating to the role of gene expression in hippocampal LTP and a discussion of recent work on the subject will be presented.

Selective targeting of mRNA and the following protein synthesis of CaMKIIα at the long-term potentiation-induced site

The results suggest that dendritic translation of CaMKIIα is locally mediated where L-LTP is induced, suggesting that this phenomenon may be one of the essential processes for memory establishment.



Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization.

The results indicate that the two mechanistically distinctive forms of LTP, a transient, early component (E-LTP) and a more enduring form (L- LTP), can be recruited selectively by changing the number of conditioning tetanic trains.

Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitors of protein synthesis

  • P. StantonJ. Sarvey
  • Biology, Chemistry
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1984
It is demonstrated that a variety of protein synthesis inhibitors are able to block the production of LTP in field CA1, suggesting the necessity for a set of newly synthesized or rapidly turned over proteins for hippocampal LTP.

Requirement of a critical period of transcription for induction of a late phase of LTP.

It was found that the induction of L-LTP was selectively prevented when transcription was blocked immediately after tetanization or during application of cAMP, suggesting that the late phase of LTP in the CA1 region requires transcription during a critical period.

Factors regulating the reversibility of long-term potentiation

  • U. StaubliD. Chun
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1996
The present in vitro studies confirm that the susceptibility of LTP to reversal and the degree of depotentiation are time-dependent and suggest that the mechanisms responsible for LTP reversal are linked to the amplitude and/or duration of fast excitatory currents mediated by synaptic AMPA receptors.

A synaptic model of memory: long-term potentiation in the hippocampus

The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.

Changes in protein synthesis accompanying long-term potentiation in the dentate gyrus in vivo

The results indicate that LTP is associated with a complex pattern of changes in protein synthesis, and reductions as well as increases in spot intensities were observed.