Synaptic tagging and long-term potentiation

@article{Frey1997SynapticTA,
  title={Synaptic tagging and long-term potentiation},
  author={U. Frey and R. Morris},
  journal={Nature},
  year={1997},
  volume={385},
  pages={533-536}
}
  • U. Frey, R. Morris
  • Published 1997
  • Biology, Medicine
  • Nature
  • Repeated stimulation of hippocampal neurons can induce an immediate and prolonged increase in synaptic strength that is called long-term potentiation (LTP)—the primary cellular model of memory in the mammalian brain1. An early phase of LTP (lasting less than three hours) can be dissociated from late-phase LTP by using inhibitors of transcription and translation2–8. Because protein synthesis occurs mainly in the cell body9–12, whereas LTP is input-specific, the question arises of how the synapse… CONTINUE READING
    1,407 Citations

    Topics from this paper.

    Synaptic capture-mediated long-lasting long-term potentiation is strongly dependent on mRNA translation
    • 9
    Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD
    • 285
    Synaptic tagging and capture in the living rat
    • 42
    • PDF
    TrkB as a Potential Synaptic and Behavioral Tag
    • 99
    • PDF
    Basolateral amygdala stimulation does not recruit LTP at depotentiated synapses
    • 7
    Gene Expression in Hippocampal Long-Term Potentiation
    • S. Dudek, R. Fields
    • Medicine, Biology
    • The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
    • 1999
    • 5

    References

    SHOWING 1-10 OF 24 REFERENCES
    Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitors of protein synthesis
    • P. Stanton, J. Sarvey
    • Biology, Medicine
    • The Journal of neuroscience : the official journal of the Society for Neuroscience
    • 1984
    • 355
    • PDF
    Factors regulating the reversibility of long-term potentiation
    • U. Staubli, D. Chun
    • Biology, Medicine
    • The Journal of neuroscience : the official journal of the Society for Neuroscience
    • 1996
    • 166
    • PDF
    A synaptic model of memory: long-term potentiation in the hippocampus
    • 10,412
    • PDF
    Changes in protein synthesis accompanying long-term potentiation in the dentate gyrus in vivo
    • 90
    • PDF