Synaptic structural dynamics and aging.

  title={Synaptic structural dynamics and aging.},
  author={Carlo Bertoni-Freddari and Patrizia Fattoretti and Roberta Paoloni and Ugo Caselli and Luciano Galeazzi and William A. Meier-Ruge},
  volume={42 3},
Synaptic junctional areas are not immutable structures, on the contrary, they are remodelled throughout the individual's lifespan as a consequence of environmental stimulations. This adaptive capacity of the synapses is discussed from a morphological standpoint with reference to aging. In old subjects, the number of contacts and the total surface area of synaptic appositions per unit volume of tissue decrease significantly, while the average synaptic size increases at a different extent… CONTINUE READING

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