Synaptic strength modulation after cortical trauma: a role in epileptogenesis.

@article{Avramescu2008SynapticSM,
  title={Synaptic strength modulation after cortical trauma: a role in epileptogenesis.},
  author={Sinziana Avramescu and Igor Timofeev},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 27},
  pages={6760-72}
}
Traumatic brain injuries are often followed by abnormal hyperexcitability, leading to acute seizures and epilepsy. Previous studies documented the rewiring capacity of neocortical neurons in response to various cortical and subcortical lesions. However, little information is available on the functional consequences of these anatomical changes after cortical trauma and the adaptation of synaptic connectivity to a decreased input produced by chronic deafferentation. In this study, we recorded… CONTINUE READING

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