Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3.

@article{Ma2011SynapticSO,
  title={Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3.},
  author={Tao Ma and Nikos A Tzavaras and Panayiotis Tsokas and Emmanuel M. Landau and Robert D. Blitzer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 48},
  pages={17537-46}
}
The persistent or "late" phase of long-term potentiation (L-LTP), which requires protein synthesis, can be induced by relatively intense synaptic activity. The ability of such strong synaptic protocols to engage the translational machinery and produce plasticity-related proteins, while weaker protocols activate only posttranslational processes and transient potentiation (early LTP; E-LTP), is not understood. Among the major translation control pathways in neurons, the stimulation of mammalian… CONTINUE READING
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GSK-3b at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways

  • F Vigneron, P Dos Santos, +5 authors B Jaspard-Vinassa
  • Cardiovasc Res
  • 2011
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