Synaptic representation of locomotion in single cerebellar granule cells

@inproceedings{Powell2015SynapticRO,
  title={Synaptic representation of locomotion in single cerebellar granule cells},
  author={Kate A. Powell and Alexandre Mathy and Ian Duguid and Michael H{\"a}usser and Indira M Raman},
  booktitle={eLife},
  year={2015}
}
The cerebellum plays a crucial role in the regulation of locomotion, but how movement is represented at the synaptic level is not known. Here, we use in vivo patch-clamp recordings to show that locomotion can be directly read out from mossy fiber synaptic input and spike output in single granule cells. The increase in granule cell spiking during locomotion is enhanced by glutamate spillover currents recruited during movement. Surprisingly, the entire step sequence can be predicted from input… CONTINUE READING
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