Synaptic reorganization by mossy fibers in human epileptic fascia dentata

@article{Babb1991SynapticRB,
  title={Synaptic reorganization by mossy fibers in human epileptic fascia dentata},
  author={Thomas L. Babb and W. R. Kupfer and James K. Pretorius and Paul H. Crandall and Michel F. L{\'e}vesque},
  journal={Neuroscience},
  year={1991},
  volume={42},
  pages={351-363}
}
This study was designed to identify whether synaptic reorganizations occur in epileptic human hippocampus which might contribute to feedback excitation. In epileptic hippocampi, (n = 21) reactive synaptogenesis of mossy fibers into the inner molecular layer of the granule cell dendrites was demonstrated at the light microscopic and electron microscopic levels. There was no inner molecular layer staining for mossy fibers in autopsy controls (n = 4) or in controls with neocortex epilepsy having… Expand
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Electrophysiological evidence of monosynaptic excitatory transmission between granule cells after seizure-induced mossy fiber sprouting.
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The results are morphological evidence of mossy Fiber synaptic reorganization in the temporal lobe of epileptic humans, and suggest the intriguing possibility that mossy fiber sprouting and synaptic reorganizing induced by repeated partial complex seizures may play a role in human epilepsy. Expand
Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy
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