Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death.

@article{Rothman1984SynapticRO,
  title={Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death.},
  author={Stephen Rothman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1984},
  volume={4 7},
  pages={1884-91}
}
  • Stephen Rothman
  • Published 1984 in
    The Journal of neuroscience : the official…
The pathophysiology of hypoxic neuronal death, which is difficult to study in vivo, was further defined in vitro by placing dispersed cultures of rat hippocampal neurons into an anoxic atmosphere. Previous experiments had demonstrated that the addition of high concentrations of magnesium, which blocks transmitter release, protected anoxic neurons. These more recent experiments have shown that gamma-D-glutamylglycine (DGG), a postsynaptic blocker of excitatory amino acids, was highly effective… CONTINUE READING