Synaptic release generates a tonic GABA(A) receptor-mediated conductance that modulates burst precision in thalamic relay neurons.

Abstract

Tonic inhibition has emerged as a key regulator of neuronal excitability in the CNS. Thalamic relay neurons of the dorsal lateral geniculate nucleus (dLGN) exhibit a tonic GABA(A) receptor (GABA(A)R)-mediated conductance that is correlated with delta-subunit expression. Indeed, consistent with the absence of delta-subunit expression, no tonic conductance is… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Cited By

Sort by:

mGluR control of interneuron output regulates feedforward tonic GABAA inhibition in the visual thalamus.

Adam C Errington, Giuseppe Di Giovanni, Vincenzo Crunelli, David W Cope
The Journal of neuroscience : the official…
2011

Augmentation of Tonic GABAA Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABAA Receptors

Adam C. Errington, David W. Cope, Vincenzo Crunelli
Advances in pharmacological sciences
2011

The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus.

Joseph Glykys, Istvan Mody
The Journal of physiology
2007

Cortical oscillatory dynamics and benzodiazepine-site modulation of tonic inhibition in fast spiking interneurons

Emma J. Prokic, Cathryn Weston, +5 authors Gavin L. Woodhall
Neuropharmacology
2015

Extrasynaptic GABAA Receptors

Adam C. Errington, Giuseppe Di Giovanni, Vincenzo Crunelli
The Receptors
2014

Tonic inhibition enhances fidelity of sensory information transmission in the cerebellar cortex.

Ian Duguid, Tiago Branco, Michael London, Paul Chadderton, Michael Häusser
The Journal of neuroscience : the official…
2012

Developmental changes of GABA immunoreactivity in cortico-thalamic networks of an absence seizure model

Cristiano Bombardi, Marcello Venzi, Vincenzo Crunelli, Giuseppe Di Giovanni
Neuropharmacology
2018

Phase-amplitude coupled persistent theta and gamma oscillations in rat primary motor cortex in vitro

Nicholas W. Johnson, Mazhar Özkan, +6 authors Gavin L. Woodhall
Neuropharmacology
2017

Adenosine A1 Receptor Suppresses Tonic GABAA Receptor Currents in Hippocampal Pyramidal Cells and in a Defined Subpopulation of Interneurons.

Diogo M Rombo, Raquel B Dias, Sofia T Duarte, Joaquim A Ribeiro, Karri P Lamsa, Ana M Sebastião
Cerebral cortex
2016

Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus

Polona Jager, Zhiwen Ye, +7 authors Alessio Delogu
Nature communications
2016

References

Sorry, we couldn't extract any references for this paper.

Slides referencing similar topics

Huge Cortico - Thalamic Projection
Chris Brown • Oct 26, 2016
Thalamic Nucleus Primary Cortex Secondary Cortex Association Cortex
Oct 07, 2016
A Series of Unfortunate Events: Bilateral Thalamic Injury
Stephanie van Rooy + 2 • Sep 24, 2016
Show More